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11月1日讲座——中山大学周天寿教授:Inferring transcriptional burst kinetics and feedback type from scRNA-seq data

作者:田燕宁  编辑:院科研办   发布日期: 2022-10-27   来源:院科研办  

讲座题目:Inferring transcriptional burst kinetics and feedback type from scRNA-seq data

主 讲 人:周天寿 教授(中山大学)

讲座时间:2022111日(周二)上午9:30-10:30

讲座地点:钱伟长楼201会议室、腾讯会议室470-984-426

欢迎有兴趣的师生前来聆听!

理学院

20221027

讲座内容简介:

We develop an interpretable and scalable statistical framework, which combines experimental data with a mechanistic model to infer transcriptional burst kinetics (sizes and frequencies) and feedback regulations. Applying this framework to the scRNA-seq data of embryonic mouse fibroblast cells, we find that genome-wide burst kinetics exhibit different characteristics in cases without and with feedback regulations, implying Simpson’s paradoxes. We show that feedbacks modulate burst frequencies and sizes differently and conceal the effects of transcription start site distributions on burst kinetics. Notably, only in the presence of positive feedback, TATA genes are expressed with high burst frequencies, and enhancer-promoter interactions mainly modulate burst frequencies.

主讲人简介:

周天寿,中山大学数学学院教授、博士生导师,广东省计算数学重点实验室副主任,中国运筹学会计算系统生物学专业委员会主任。研究方向:计算系统生物学。在SCI刊物发表200余篇论文,包括国际重要学术刊物PNASPRL。在科学出版社出版学术专著2部。2008年获国家自然科学二等奖。主持多项国家级科研项目,包括主持国家基金委重点项目2项,主持国家基金委重大研究计划/重点支持项目和集成项目各1项,主持973课题1项等。目前担任四个国际学术刊物的编委,包括国际著名综述性期刊:Current Opinions in Systems Biology.