讲座题目：Coherent Raman Microscopy and Its Biomedical Imaging Applications
主 讲 人：Fake Frank Lu教授
讲座时间：2017年11月2日下午14:00
讲座地点：理学院钱伟长楼201报告厅
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讲座内容简介：
Label-free optical microscopy is an emerging technology in biology and medicine to perform live imaging without affecting cell functions or in vivo imaging of human with no fluorescent staining. While Raman spectroscopy has been used for molecular characterization for cancer detection with high sensitivity, imaging speed is always an issue. By coherently exciting and detecting the chemical bond vibration in molecules, coherent Raman scattering (CRS) microscopy, with two modalities of coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), has been used for label-free imaging of various biomolecules or drugs with high spatiotemporal resolution and high chemical specificity.
In this seminar, I will first review recent technical efforts that have greatly improved CRS imaging speed, detection sensitivity and spectral acquisition, and I will further present several label-free biomolecular imaging applications of the technology. In particular, transforming SRS microscopy for clinical use is a major direction of my research. The methodology of SRS label-free histopathology for rapid cancer detection and image-guided precision surgery has shown a great potential to impact on the current clinical practices of pathology and surgery.
His current research aims to establish an advanced biophotonics program focusing on coherent Raman and multiphoton microscopy technologies for imaging of living cells, in vivo animals and fresh human tissue at the most translational frontier for neuro-oncology and neuroscience studies.
主讲人简介：
Fake Frank Lu (鲁法珂) 博士，纽约州立大学和滨汉姆妇幼医院教授，主要从事基于非线性光学技术的肿瘤诊段和基因检测等方面的研究工作，其中基于光学手段的唐氏综合征筛选技术处于国际领先水平，多次主持美国NIH K99/R00等项目，在Nature Comm、PNAS、JACS、Cancer Research、APL、OL等国际顶级期刊发表论文二十余篇发表。2011年毕业于新加坡国立大学光学工程专业，曾任美国哈佛大学和哈佛医学院资深研究员，研制出亚洲第一台反斯托克斯拉曼散射显微镜，为肿瘤的早期诊断和治疗奠定基础，所研究的SRS高分辨成像被认为是最有希望率先在分子水平实现肿瘤特征物质检测的关键技术，是美国生物光学领域著名的年轻华人科学家之一。
