Wuxi Biocomputing Engineering Technology Research Center (abbreviated as “Center”) based on research in bioinformatics at School of Science in Jiangnan University, key laboratory of industrial biotechnology of the Ministry Education in Jiangnan University, Industrial microorganism resource platform in Chinese universities, research team of national engineering center for fermentation technology and molecular computation, was founded in June, 2012 by Wuxi technology office. This Center aims at calculation and structure simulation of biomacromolecules, biological information processing by means of mathematical modeling and big data processing, integrating mathematics, life science and computation science. It has an illustrative for others.
The Center engages the noted experts in the field of bioinformatics as advisers, Professor Luonan Chen at Shanghai Institutes for biological sciences, the Chinese Academy of Sciences and Professor Kui Lin at School of Life Science, Beijing Normal University. There are 3 research directions, more than 20 research staffs among them 12 with senior titles, and 16 doctoral students. The Center provides 300 square meters of office space, 500 square meters of laboratory space, and 600 square meters for experiment examination with equipment costing 3.5 million yuan. In recent 3 years, the Center undertakes about 20 provincial and national programs with funds of 7 million yuan. More than 40 papers are published in SCI indexed journals including IEEE Transactions on Fuzzy Systems, Mathematics and Computers in Simulation, International Journal of Biomathematics, Applied Mathematics and Computation, Neurocomputing among them the highest impact factor of 5.484.
1. Research Directions:
Platform of Disease Control and Drug Effect Analysis
establish the mathematical models of gene regulation effect based on molecular structure, use the mathematical models describing interaction of molecular in biological tissues to explain structure of protein, reconstruct and analyze lots of observational and experimental data, tract and discover the scope and change region of disease gene, introduce research on functional genomics and genes with important traits; through the construction and application of genetics databases, build distributed biological database system, analyze the data consolidation of related molecular biology and technology of genomic databases, construct the prediction, analysis, reconstruction and modeling techniques and software development of the gene regulatory network, epigenetic network, signal transduction, biochemical metabolism. These would explain the role of genetic element in various diseases including the severe ones harmful to human health such as cancer.
Platform of Environment and Ecological Treatment and Assessment
Focus on research frontiers of circadian clocks internationally based on blue-green algae clock, promote the basic research on theoretical models of circadian clocks, provide new thought and experience for other biological clocks in application, build and improve the platform of environment and ecological treatment and assessment. Our research would provide theoretic background and application guidance for blue-green algae pollution in Lake Taihu.
Platform of Control on Fermentation Process
According to characteristics of the fermentation process, acquire and control the data of field; realize the real-time connection with upper management information system by high speed, reliable and open system analysis; achieve optimal control and safety practices of fermentation process, develop friendly man-machine interface; supervise, control and optimize fermentation process in real-time, safe and reliable, establish gradually the platform of control on fermentation process.
2.List of Programs
Study on Modelling, Analysis and Algorithms of Biological Network Structure Based on Granular Computation, the national natural science foundation of China general Program (No. 11371174), 2014.1-2017.12，0.62 million, Project leader: Xuqing Tang, completed;
Study on Model Analysis and Simulation of Underground Flow, part of the international technological cooperative key project of ministry of science and technology (No. 2011DFR70500), 2012.1-2016.12, 1.05 million, Project leader: Xuqing Tang, completed;
Study on Mathematical Modelling and Algorithms of Regulation of p53 Tumor Suppressor Genes, the national natural science foundation of China general grogram (No. 11271163), 2013.1-2016.12, 0.68 million, Project leader: Ping Zhu, completed;
Mathematical Modelling and Simulation of Blue-Green Algae Clock, the national natural science foundation of China youth program (No. 10901073), 2010.1-2012.12，0.17 million, Project leader: Manfeng Hu, completed;
Modelling Theory, Method and Application of Gene Regulatory Network, fundamental research funds for the central universities (No. JUSRP51317B), 2013.1-2015.12，0.8 million, project leader: Manfeng Hu, completed;
New Algorithm of Fuzzy Intelligence for Special Protein Signal Peptide Sequences, the national natural science foundation of China youth program (No. 61402202), 2015.1-2017.12，0.25 million, Project leader: Cuifang Gao, completed;
Chaotic Synchronization of Stochastic Dynamical Systems, the national natural science foundation of China youth program (No. 11202084), 2013.1-2015.12，0.23 million, Project leader: Aihua Hu, completed;
Analysis and Application of Global Geometric Characteristics of Mixed Quasi Bézier Curves in CAD, the national natural science foundation of China youth program (No. 61402201), 2015.1-2017.12，0.26 million, Project leader: Wanqiang Shen, completed;
Study on the Theory and Application of Quasi Bernstein- Bézier Triangular Surface in CAD, the natural science foundation of Jiangsu Province youth program (No. BK20130117), 2013.7-2016.6，0.20 million, Project leader: Wanqiang Shen, completed;
Study on the Properties and Application of B Splines in CAD , the national natural science foundation of China Tianyuan program (No. 11326243), 2014.1-2014.12，0.03 million, Project leader: Wanqiang Shen, completed;
Regularization Theory and Algorithms for Several Kinds of Ill-posed Problems, the natural science foundation of Jiangsu Province youth program (No. BK BK20130118), 2013.7-2016.6，0.2 million, Project leader: Hao Chen, completed;
Regularization Theory and Algorithm for Inverse Problem of Fractional Diffusion Equation, the national natural science foundation of China Tianyuan program (No. 11426117), 2015.1-2015.12，0.03 million, Project leader: Hao Chen, completed.
3. Representative Publications
Xu-Qing Tang and Ping Zhu, Hierarchical Clustering Problems and Analysis of Fuzzy Proximity Relation on Granular Space, IEEE Transactions on Fuzzy Systems，21(5), 814-824, 2013. (SCI)
Yong-Qing Yang, Jin-De Cao, Xian-Yun Xu, Man-Feng Hu and Yun Gao, A New Neural Network for Solving Quadratic Programming Problems with Equality and Inequality Constraints, Mathematics and Computers in Simulation, 101, 103-112, 2014. (SCI)
Yong-Qing Yang, Jin-De Cao, , Xian-Yun Xu and Jiao Liu, A Generalized Neural Network for Solving a Class of Minimax Optimization Problems with Linear Constraints, Applied Mathematics and Computation, 218(14), 7528–7537, 2012. (SCI)
Cheng-Jie Tan, Shan-Shan Li and Ping Zhu, 4D Graphical Representation Research of DNA Sequences, International Journal of Biomathematics, 8(1), 1550004, 2015. (SCI)
Man-Feng Hu, Liu-Xiao Guo, Ai-Hua Hu and Yong-Qing Yang, Leader-Following Consensus of Linear Multi-agent Systems with Randomly Occurring Nonlinearities and Uncertainties and Stochastic Disturbances, Neurocomputing, 149, 884-890, 2015. (SCI)
Man-Feng Hu, Jin-De Cao, Ai-Hua Hu, Yong-Qing Yang and Ying-Hua Jin, A Novel Finite-Time Stability Criterion for Linear Discrete-Time Stochastic System with Applications to Consensus of Multi-Agent System, Circuits, Systems, and Signal Processing, 34(1): 41-59, 2015. (SCI)
Jie Gao, Ling Zhang and Pei-Xuan Jin, Forecasting Influenza Epidemic based on Mutation Probability of HA/NA Protein, Journal of Pure and Applied Microbiology, 7(2), 1251-1254, 2013. (SCI)
Jie Gao, Ling Zhang and Pei-Xuan Jin, Influenza Pandemic Early Warning Research on HA/NA Protein Sequences, Current Bioinformatics, 9(3), 228-233, 2014. (SCI)
Ai-Hua, Hu, Jin-De Cao, Man-Feng Hu and Liuxiao Guo, Cluster Synchronization of Complex Networks via Event-triggered Strategy under Stochastic Sampling, Physica A: Statistical Mechanics and its Applications, 434, 99-110, 2015. (SCI)
Wan-Qiang Shen, Guo-Zhao Wang and Ping Yin, Explicit Representations of Changeable Degree Spline Basis Functions, Journal of Computational and Applied Mathematics, 238, 39-50, 2013. (SCI)
Hao Cheng, Chu-Li Fu, Guang-Hui Zheng and Jie Gao, A Regularization for a Riesz-Feller Space-Fractional Backward Diffusion Problem, Inverse Problems in Science and Engineering, 22(6), 860-872, 2014. (SCI)
4.Academic Activities
（1）seminar of members of center
（2）A Lecture by Professor Luonan Chen from Chinese Academy of Sciences
（3） members of center on a tour of investigation
（4）a large server at center
5. Contact Information
Address: 1800 Lihu Avenue, School of Science, Jiangnan University, Jiangsu Province, China
Postcode: 214122
Responsible: Ping Zhu
Person in contact: Hao Chen
Telephone number: 0510- 85329094
Fax: 0510-85910532
E-mail：chenghao@jiangnan.edu.cn
